Construction, development of tools for application, and practicality of marmoset brain atlases available anew
Organizer Tsutomu Hashikawa
Neuroinformatics Japan Center
In this session T. Hashikawa, A. Woodward and T. Kaneko will present their works concerning with the usefulness of recently developed brain atlases of the common marmoset.
Why is the marmoset now? Along with biological sciences, the marmoset can be a useful animal model in neuroscience research . This is because among the primates, the common marmoset 1) is available at a relatively low price with mature adults being small I size (300g or so) . Thus, it is easier to house and handle these monkeys in a laboratory setting; 2) shows high fertility (giving birth to non-identical twins twice/year) and earlier sexual maturity (~ 15 months) [3, 4]. This means that certain genetic aspects of neural functions can be analyzed , which is important given that most genetic studies that have taken place so far have been conducted in mice; 3) has a structurally well-developed brain sharing similar characteristics across various primate species . Common features of brain structures in primate make rather direct comparisons possible among the species, and comparative approach seems especially important in marmoset studies.
Since relatively limited information is available regarding the common marmoset itself, data collected on other primates have been helpful when considering correlations between structure and function in the marmoset brain. Thus combination of knowledge of research on Old World primates and new insight from genetic approaches in marmosets will provide a better, more comprehensive understanding of brain functions.
Construction of the marmoset brain atlas in a stereotaxic coordinates, on the basis of Nissl stained horizontal sections
Tsutomu HASHIKAWA, Neuroinformatics Japan Center, RIKEN Brain Science Institute
3D Image Registration Techniques for Multi-modal 3D Brain Atlas Construction
Alexander WOODWARD, Neuroinformatics Japan Center, RIKEN Brain Science Institute
Structural and functional mapping of the marmoset brain using MRI
Takaaki KANEKO, RIKEN Brain Science Institute